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1970-01-01 08:00
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2021年1月23日发(作者:stinging)
Sentence Template for Notebook and Report Writing
Pfizer Project Management Team
April 12, 2007
Part 1:
反应前的装置描述

1.1:
A 3 L three-necked round bottom flask equipped with mechanical stirrer (or
magnetic
stirrer), addition funnel and thermometer (or Dean-Stock; drying tube)
1.2:
All flasks used in the reaction were heated under vacuum for 30 minutes and
purged with
N
2
for 10 minutes. (
无水反应装置
)
Part 2:
加料

2.1:
不同的顺序和表达

2.1.1:
A 3 L three-necked round bottom flask equipped with mechanical stirrer (or
magnetic
stirrer), addition funnel and thermometer (or Dean-Stock; drying tube) were charged
with
A
(10 mL, 1 mole),
B
(2 g, mole) and
C
(50 mL),
2.1.1.1:
a solution of
D
(10 g, 1 mole) in
E
(20 mL) was added dropwise (via addition
funnel
or syringe) at 10
o
C (or while maintaining gentle reflux; while keeping inner
temperature
between 10
o
C

30
o
C) under N
2
(液体滴加到反应液中)

2.1.1.2: D
(10 g, 1 mole) was added in portions during a period of 1 hr (
固体分批加
入到反

应液中
)
2.1.1.3
:
D
(10 g, 1 mole) and
E
(20 mL) were added in turn
2.2:
To a solution (mixture, suspension or slurry) of
A
(10 mL, 1 mole) and
B
(2 g, mole)
in
C
(50
mL)
2.2.1:
was added dropwise a solution of
D
(10 g, 1 mole) in
E
(20 mL) with stirring at
10
o
C
(or while maintaining gentle reflux; while keeping inner temperature between 10
o
C


30
o
C)
under N
2
2.2.2:
was added
D
(10 g, 1 mole) in portions during a period of 1 hr
Sentence Template for Notebook and Report Writing
WuXiPharmaTech Co., Ltd.
Confidential
Page 2 of 7
2.2.3:
were added
D
(10 g, 1 mole) and
E
(20 mL) in turn
2.3:
2.3.1:
A solution of
D
(10 g, 1 mole) in
E
(20 mL) was added dropwise into a solution
(mixture or suspension) of
A
(10 mL, 1 mole) and
B
(2 g, mole) in
C
(50 mL) at 10
o
C
(or
while maintaining gentle reflux; while keeping inner temperature between 10
o
C


30
o
C) under
N
2
2.3.2: D
(10 g, 1 mole) was added into a solution (mixture or suspension) of
A
(10 mL,
1
mole) and
B
(2 g, mole) in C (50 mL) in portions
2.3.3: D
(10 g, 1 mole) and
E
(20 mL) were added into a solution (mixture or
suspension) of
A
(10 mL, 1 mole) and
B
(2 g, mole) in
C
(50 mL) in turn
2.4:
2.4.1:
A solution of BuLi or BH
3
/THF (10 mL, 1 mole, 2.5 M in hexane) was
cannulated into
addition funnel or into a solution
A
in solvent
B
2.4.2:
A solution of BuLi or BH
3
/THF (10 mL, 1 mole, 2.5 M in hexane) was added
into a
solution of
A
in solvent
B
via cannula, dropping funnel or syringe over a period of hrs
Part 3:
反应

3.1:
无溶剂反应

A
(1 g, 1 mol) and
B
(1 g, 1 mol) were dissolved in solvent
C
, evaporated to dryness
and
heated for x hours at x
o
C
3.2:
催化量的反应

A
(20 mL, 142 mmol) and catalytic amount (a trace amount or two drops) of
B
were
added
into a solution of
C
(4.549 g, 46.4 mmol) in
D
(120mL) at 0
o
C
3.3:
闷罐反应或封管反应

A solution of
A
(x g, x mol) in methanol (x mL) saturated with NH
3
(or other gas such
as: CO,
CO
2
, H
2
S) was stirred under 50 Psi at x
o
C for x hours in a 50 mL of sealed tube or
autoclave.
Sentence Template for Notebook and Report Writing
WuXiPharmaTech Co., Ltd.
Confidential
Page 3 of 7
3.4:
有气体参与的反应

3.4.1:
A solution of
A
(x g, x mol) in methanol (x mL) saturated with HCl was stirred
at x

.
3.4.2:
Ozone was bubbled into a solution of
A
(x g, x mol) in MeOH (x mL) at x
o
C
for 15
minutes. After excess O
3
was purged by N
2
, Me
2
S (x mL) was added at x
o
C.
3.4.3:
Gas was bubbled into a solution of
A
(x g, x mol) and
B
(x g, x mol) in solvent
C
(x
mL) at x
o
C for x hours.
3.5:
混合溶剂参与的反应

3.5.1:
To a solution of
A
(x g, x mol) in a mixture of solvent
B
(mL) and solvent
C
(x
mL) (or
a mixed solvent of
B
and
C
) was added
D
(x g, x mol) at x
o
C, the reaction mixture
was
allowed to stir (reflux or heat) for x hrs.
3.5.2:
To a solution of
A
(x g, x mol) in 10: 1 aqueous acetone (x mL) was added
B
(x
g, x
mol) followed by addition of
C
(x g, x mol), the reaction mixture was allowed to stir
(reflux
or heat) for x hrs.
3.6:
分水器分水的反应

3.6.1: A
(x g, x mol) and
B
(x g, x mol) in benzene or toluene (x mL) were refluxed
for x
hours with azeotropical removal of water.
3.6.2;
A mixture of
A
,
B
and TsOH.H
2
O (56.91 g, 0.3 mol) in toluene (400 mL) was
heated to
reflux and remove water by Dean-Stark trap.
3.7:
氢化反应

To a solution of
A
(x g, x mol) in EtOH (x mL) was added Pd-C or Ra-Ni or
Pd(OH)
2
/C (10%,
x g) under N
2
. The suspension was degassed under vacuum and purged with H
2
several times.
3.7.1:
The mixture was stirred under H
2
(x psi) at x

for x hours. [
氢化瓶或高压釜
]
3.7.2:
The mixture was stirred under H
2
balloon at x

for x hours. [
常压氢化如气球
反应
]
3.7.3:
A mixture of
A
(x g, x mol) and Ra-Ni (x g) in EtOH (x mL) was hydrogenated
under
50 Psi of hydrogen pressure for x hours at room temperature.
Sentence Template for Notebook and Report Writing
WuXiPharmaTech Co., Ltd.
Confidential
Page 4 of 7
Part 4:
反应条件或过程描述

4.1:
The reaction mixture (solution or suspension) was stirred at 5
o
C for 2 hrs and
then kept at
room temperature (or ambient temperature) for another 2 hrs (or overnight)
4.2:
The reaction mixture (solution or suspension) was refluxed (heated to reflux) or
heated at
60
o
C for 2 hrs (or overnight)
4.3:
The reaction mixture (solution or suspension) was allowed to reflux (or heat to
reflux) for
2 hrs (or overnight)
4.4:
The reaction mixture (solution or suspension) was allowed to warm to
temperature during
2 hrs and reflux (or heat to reflux) for 2 hrs (or overnight)
Part 5:
反应监测

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